Do you find yourself frequently struggling with sad moods, tension, or feelings of overwhelm—even if you don’t understand why you feel that way? You’re not alone.
Your body chemistry can strongly affect your mood—for better or for worse. One key regulator of your mood is a neurotransmitter called serotonin, and unfortunately there are many ways—in addition to the natural aging process—that serotonin levels in your body can decrease, causing a profound dip in your moods.
Fortunately, there are also several safe and natural strategies you can employ to help restore your mood and your body’s optimal serotonin levels.
In this article, you will learn:
- The role of serotonin in mood regulation
- How your serotonin levels can be affected by stress, your digestive health, and environmental toxins
- And how the ingredients in Juvenon’s SeroLastin can help you reverse course on your lingering feelings of worry or sadness by helping to regulate your body’s serotonin production.
Serotonin and your mood
Serotonin is a compound that’s created and used by your nerve cells. It plays important roles in brain function and mood regulation, but also many other functions throughout the body. It’s a neurotransmitter, meaning that it can send and receive signals to and from the nervous system.
Low levels of serotonin have been linked to depression, anxiety, and panic disorders.(1,2)
Additionally, selective serotonin reuptake inhibitors (SSRIs) are considered a first-line treatment for depression. These drugs actually help your body recycle serotonin so that you’re able to experience more of its benefits.
Therefore, the importance of serotonin for mood regulation can’t be overstated. Unfortunately, if you find yourself consistently sad, anxious, or upset—even if your circumstances don’t warrant those kinds of feelings—low serotonin may be behind it.
There are three main culprits that can sabotage your body’s ability to produce adequate levels of serotonin.
Short-term stress is a normal response to external threats, but long-term, chronic stress has become extremely prevalent today. And unfortunately, your body can’t function at its best when it’s always in “fight or flight” mode—as it is when you’re chronically stressed out.
When you’re stressed, your body’s circulating levels of the hormone cortisol (the “stress hormone”) increase. Cortisol causes your body to hold on to abdominal fat because it translates feelings of stress as a threat to survival, such as impending starvation. However most of our modern stressors aren’t threats to our survival. Cortisol may also cause food cravings and lead to weight gain.(3)
However, researchers have also found an interesting link between cortisol and serotonin. When cortisol is high (when you’re stressed out), your nerve cells are more likely to take up serotonin rather than allowing it to continue to circulate. This increased serotonin reuptake can lead to a functional decrease in serotonin levels, leading to a depressed mood. This is one possible way that stress may lead to depression.(4,5)
Poor gut health
Surprisingly, most of your body’s serotonin is produced in the gut—where much of your nervous system is located.
The healthy bacteria—or probiotics—living in your digestive tract actually play a huge role in this serotonin production.(6,7)
That’s why an unhealthy imbalance of gut bacteria—with large quantities of unhealthy bacteria compared to beneficial bacteria, or just low levels of beneficial bacteria in general—can throw off your body’s innate ability to produce that just right amount of serotonin.
- A diet that’s rich in fiber, which serves as a food source—or prebiotic—for the healthy bacteria that reside in your gut, alongside
- Probiotic supplements or fermented foods, which are rich sources of probiotics on their own.
Unfortunately, our modern environment is also one that can sap serotonin—causing you to feel listless or blue. Common toxins that may affect your serotonin production and that most people encounter on a regular basis include pesticides—like glyphosate and many others—and certain medications. Even air and water quality may play a role.(8,9)
This one can be difficult to tackle, but if you feel that environmental toxins are contributing to your mood, some things that may help include:
- Eating more organic produce
- Using a water filter
- Using an air purifier
How SeroLastin Can Help
Juvenon’s SeroLastin is a uniquely formulated supplement that’s designed to target the key reason that many people fall into feelings of sadness or hopelessness and are unable to shake them: low serotonin.
Each ingredient in SeroLastin is research backed to support serotonin production or to help boost mood, improve brain function, or reduce feelings of tension and sadness.
Here’s a little bit about each ingredient in SeroLastin and why it was chosen.
Saffron is a prized spice made from the flowers of the Crocus sativa plant. It’s rare and very expensive, and highly sought after not only for seasoning food but also as a natural dye and for its many potential health benefits. Some types of saffron can cost $2,000 per pound—or more!
Fortunately, even small amounts of saffron are packed with benefits. As the key ingredient in SeroLastin, we’ve included enough saffron for you to experience its potent serotonin-enhancing benefits (without its outrageous price). Researchers believe that crocins, the major active components of saffron, may be able to interact directly with the body’s serotonin system.(10)
SeroLastin is made with three key B-vitamins—vitamin B6, vitamin B12, and folate—that play key roles in brain and nervous system function.
These three vitamins are particularly important when it comes to the metabolism of a substance called homocysteine. Homocysteine is an amino acid (a building block of protein) that’s needed in small amounts for optimal health. It mostly comes from the meat in your diet.
However, when you don’t get enough vitamin B6, vitamin B12, or folate, this amino acid can build up in your blood—leading to depressive symptoms and even brain damage in some severe cases.(14, 15, 16, 17)
Here’s more about how these three B-vitamins play an important role in serotonin production and mood regulation:
- Vitamin B6: Vitamin B6 is a cofactor in the series of biochemical reactions that are used to create serotonin in your body. Low levels have been linked to depressive symptoms, and researchers have found that—in women especially—a higher vitamin B6 intake may improve mood (18, 19)
- Vitamin B12: Vitamin B12 plays several roles in the body in addition to regulating mood and optimizing brain function. Researchers have found a strong link between low vitamin B12 levels and depression.(15, 20)
- Folate: Folate (also known as vitamin B9) is widely known for its importance during pregnancy to help prevent neural tube defects in babies. However, it continues to play an important role throughout your lifespan. Low folate levels are associated with depression, and folate supplementation may help with cognitive declines related to aging and reduce anxiousness.(20)
One additional note about folate: Some people have a gene mutation known as the methylenetetrahydrofolate reductase (MTHFR) gene mutation—which can actually lead to high homocysteine levels even if you’re eating enough folate. This is because the folate you’re getting isn’t in a form that can be properly utilized by your body because of the MTHFR mutation. (15, 16)
That’s why the folate in SeroLastin is methylated. It can be effectively digested, absorbed, and utilized by people with or without the MTHFR gene mutation.
Ashwagandha is a powerful adaptogenic herb made from the Withania somnifera plant. As an adaptogen, it can help your body respond better to stress by increasing your ability to adapt (hence the name) and react in more beneficial ways to external and internal stress cues. (22)
Ashwagandha is thought to act on the hypothalamus-pituitary-adrenal (HPA) axis, a network involving your central and peripheral nervous system that controls your body’s stress response, in order to have its adaptogenic effects.
In one randomized controlled trial, researchers found that ashwagandha could significantly decrease stress, worry, and sadness in healthy, high-stress adults when compared to a placebo.(23)
Alpinia galanga root extract
Alpinia galanga, or galangal, is a relative of ginger. It’s used in traditional Chinese medicine for several different purposes—including helping to heal infections and injuries.
However, research suggests that it may also be a powerful nervous system stimulant—meaning it can help your brain function more optimally and it can decrease “brain fog,” or mental exhaustion.
Two different animal studies have shown promising results. In one, researchers noted that A. galanga root extract protected the brain and helped preserve the memories of rats with amnesia. In another, researchers noted that A. galanga worked similarly to caffeine—meaning it could potentially serve as a replacement for that afternoon cup of coffee to help you power through the day.(24, 25)
Although there are many factors that dictate your serotonin level—for good or bad—there are also some healthy lifestyle strategies you can incorporate to help you stave off sadness, worry, and anxiousness.
Managing stress, fostering healthy gut bacteria, and limiting your exposure to environmental toxins are three strategies that may help you to naturally restore serotonin balance.
In addition, using Juvenon’s SeroLastin is an effective, safe, and non-habit forming way to increase your body’s natural serotonin levels and improve your outlook.
- Dell’Osso L, Carmassi C, Mucci F, Marazziti D. Depression, Serotonin and Tryptophan. Curr Pharm Des. 2016;22(8):949-954. doi:10.2174/1381612822666151214104826
- Zangrossi H Jr, Graeff FG. Serotonin in anxiety and panic: contributions of the elevated T-maze. Neurosci Biobehav Rev. 2014;46 Pt 3:397-406. doi:10.1016/j.neubiorev.2014.03.007
- Tchernof A, Després JP. Pathophysiology of human visceral obesity: an update. Physiol Rev. 2013;93(1):359-404. doi:10.1152/physrev.00033.2011
- Tafet GE, Toister-Achituv M, Shinitzky M. Enhancement of serotonin uptake by cortisol: a possible link between stress and depression. Cogn Affect Behav Neurosci. 2001;1(1):96-104. doi:10.3758/cabn.1.1.96
- Tafet GE, Idoyaga-Vargas VP, Abulafia DP, et al. Correlation between cortisol level and serotonin uptake in patients with chronic stress and depression. Cogn Affect Behav Neurosci. 2001;1(4):388-393. doi:10.3758/cabn.1.4.388
- Strandwitz P. Neurotransmitter modulation by the gut microbiota. Brain Res. 2018;1693(Pt B):128-133. doi:10.1016/j.brainres.2018.03.015
- O’Mahony SM, Clarke G, Borre YE, Dinan TG, Cryan JF. Serotonin, tryptophan metabolism and the brain-gut-microbiome axis. Behav Brain Res. 2015;277:32-48. doi:10.1016/j.bbr.2014.07.027
- Judge SJ, Savy CY, Campbell M, et al. Mechanism for the acute effects of organophosphate pesticides on the adult 5-HT system. Chem Biol Interact. 2016;245:82-89. doi:10.1016/j.cbi.2015.12.014
- León-Olea M, Martyniuk CJ, Orlando EF, et al. Current concepts in neuroendocrine disruption. Gen Comp Endocrinol. 2014;203:158-173. doi:10.1016/j.ygcen.2014.02.005
- Georgiadou G, Tarantilis PA, Pitsikas N. Effects of the active constituents of Crocus Sativus L., crocins, in an animal model of obsessive-compulsive disorder. Neurosci Lett. 2012;528(1):27-30. doi:10.1016/j.neulet.2012.08.081
- Tóth B, Hegyi P, Lantos T, et al. The Efficacy of Saffron in the Treatment of Mild to Moderate Depression: A Meta-analysis. Planta Med. 2019;85(1):24-31. doi:10.1055/a-0660-9565
- Lopresti AL, Drummond PD. Saffron (Crocus sativus) for depression: a systematic review of clinical studies and examination of underlying antidepressant mechanisms of action. Hum Psychopharmacol. 2014;29(6):517-527. doi:10.1002/hup.2434
- Bostan HB, Mehri S, Hosseinzadeh H. Toxicology effects of saffron and its constituents: a review. Iran J Basic Med Sci. 2017;20(2):110-121. doi:10.22038/ijbms.2017.8230
- Malouf R, Grimley Evans J. The effect of vitamin B6 on cognition. Cochrane Database Syst Rev. 2003;(4):CD004393. doi:10.1002/14651858.CD004393
- Coppen A, Bolander-Gouaille C. Treatment of depression: time to consider folic acid and vitamin B12. J Psychopharmacol. 2005;19(1):59-65. doi:10.1177/0269881105048899
- Graydon JS, Claudio K, Baker S, et al. Ethnogeographic prevalence and implications of the 677C>T and 1298A>C MTHFR polymorphisms in US primary care populations. Biomark Med. 2019;13(8):649-661. doi:10.2217/bmm-2018-0392
- Saraswathy KN, Ansari SN, Kaur G, Joshi PC, Chandel S. Association of vitamin B12 mediated hyperhomocysteinemia with depression and anxiety disorder: A cross-sectional study among Bhil indigenous population of India. Clin Nutr ESPEN. 2019;30:199-203. doi:10.1016/j.clnesp.2019.01.009
- Hvas AM, Juul S, Bech P, Nexø E. Vitamin B6 level is associated with symptoms of depression. Psychother Psychosom. 2004;73(6):340-343. doi:10.1159/000080386
- Kafeshani M, Feizi A, Esmaillzadeh A, et al. Higher vitamin B6 intake is associated with lower depression and anxiety risk in women but not in men: A large cross-sectional study. Int J Vitam Nutr Res. 2020;90(5-6):484-492. doi:10.1024/0300-9831/a000589
- Petridou ET, Kousoulis AA, Michelakos T, et al. Folate and B12 serum levels in association with depression in the aged: a systematic review and meta-analysis. Aging Ment Health. 2016;20(9):965-973. doi:10.1080/13607863.2015.1049115
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- Lopresti AL, Smith SJ, Malvi H, Kodgule R. An investigation into the stress-relieving and pharmacological actions of an ashwagandha (Withania somnifera) extract: A randomized, double-blind, placebo-controlled study. Medicine (Baltimore). 2019;98(37):e17186. doi:10.1097/MD.0000000000017186
- Hanish Singh JC, Alagarsamy V, Diwan PV, Sathesh Kumar S, Nisha JC, Narsimha Reddy Y. Neuroprotective effect of Alpinia galanga (L.) fractions on Aβ(25-35) induced amnesia in mice. J Ethnopharmacol. 2011;138(1):85-91. doi:10.1016/j.jep.2011.08.048
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