Anti-Aging and Immune Health: Two Sides of the Same Coin

It’s that time of year again — temps are dropping, leaves are falling, and people will soon be spending way more time indoors as winter approaches. Unfortunately, that also means the triple-whammy of colds, influenza, and COVID-19. 

Knowing that age is a risk factor for a more severe course of illness for any of these, it’s wise to lead a lifestyle that both supports your natural immune system and provides anti-aging benefits to promote optimal health.

In this article, you will learn:

• How aging and immune health are intricately connected,
• Which lifestyle changes offer both immune boosting and anti-aging properties,
• And how the ingredients in Juvenon’s aptly named Immune Wellness formula were specifically chosen to strengthen your immune system for your best health.

Aging and immune health

Immunosenescence — or “aging of the immune system” — is a natural part of aging. As the body ages, it experiences a lowered ability to ward off harmful pathogens, more severe disease compared to younger people with more robust immune systems, a lesser response to vaccinations, increased amounts of oxidative stress, and dysregulation in both cell reproduction.[1]

Fortunately, there are many ways that you can keep yourself — and your immune system — as healthy as possible despite aging.

Lifestyle changes to optimize immune health and reverse aging

What are the lifestyle factors that may make a difference in your immune health?

The very same ones that promote overall wellness and provide anti-aging benefits. These include:

  • Eating healthy and nutrient rich foods. Did you know that there is such a thing as the “anti-aging diet?” Researchers believe that polyphenols, or compounds found in plants, are the key to longevity. These polyphenols are rich in fruits, vegetables, whole grains, and healthy fats like olive oil, coconut oil, and avocado oil. These antioxidant polyphenols help to prevent free radical damage to your cells and promote optimal cell functioning and production.[2]
  • Avoiding sugar and highly processed foods. Added sugar is extremely common in our diets today, but unfortunately it can be devastating for your health. The body can’t process large amounts of sugar healthfully, so it promotes cellular dysfunction and weight gain — which promotes further cellular dysfunction. To optimize your health, try to avoid sugar and highly processed foods.[3]
  • Exercising regularly. Exercise is another fundamentally important part of a healthy lifestyle. We know it’s anti-aging benefits, and that it can help maintain strong bones and muscles and help regulate your mood and promote heart health. However, it also plays a role in the immune system. Regular exercise supports a more robust immune response to invader cells, and may even help the body develop a stronger immunity against the flu after receiving a flu vaccination. Experts say to aim for 150-300 minutes per week, along with two resistance training sessions.[4]
  • Getting enough sleep. Sleep is vitally important. It’s restorative and healing, helping to improve and optimize both your mental and physical health. Sleep and immunity are also intricately connected, as poor sleep can increase your susceptibility to disease but getting rest helps you to better ward off infections. Most adults need 7-9 hours each night.[5]
  • Minimizing stress. Additionally, stress is a key consideration. If you’re constantly frazzled, anxious, stressed, busy, worked up, and so on, then you’ll experience some hormonal changes that may harm your health. In the past these short term hormone changes might have provided some protection, but now that we are always stressed out these changes can promote weight gain and health dysregulation. Stress also may contribute to poor food decisions and sleep disturbances, which may make you more stressed. Try to keep your stress at bay with activities you enjoy, spending time with your loved ones, yoga, or meditation.[6]
  • Choosing the right supplements. Supplements can be a great way to support your goals whether you are doing all of the other things on this list faithfully, or if you’re just getting started on your journey to improve your health. One that should be on your radar is Juvenon’s Immune Wellness, an expert-designed blend of nutrients and antioxidants that targets both immune system and health optimization.

Juvenon’s Immune Wellness

Juvenon’s Immune Wellness formula was designed for a two-fold purpose: to help promote optimal wellness, and to help strengthen the body’s immune system. Because there’s so much overlap in these two functions — after all, a healthy immune system is part of a healthy body — this supplement is formulated with some powerhouse ingredients that can really make a difference with just 1 or 2 capsules a day.

Beta-glucan

Beta-glucan is a type of soluble fiber found in sources like oatmeal, yeast, and mushrooms. However, it’s not just a fiber — it’s a bioactive compound with several health-optimizing potential benefits.[7]

It plays an interesting role in both anti-aging and immune boosting applications because it can help “train” immune cells to fight off certain invaders, resulting in a more robust response by your immune system in the presence of these pathogens.[8]

In addition, animal studies have noted beta-glucan had a direct impact on lifespan. One study in fish found that beta-glucans prolonged their lifespan, while a rat study noted that beta-glucan could prevent “immunosenescence” or immune-aging in aged mice.[9, 10]

Quercetin

Quercetin is a powerful antioxidant found in many fruits and vegetables. 

It may help regulate the immune system and promote a healthy, normal immune response to all types of cells — meaning, your immune cells are correctly able to recognize invader organisms and only attack those.[11]

Quercetin may also help to inhibit the mTOR pathway, which is associated with aging. In this way, researchers have noted that quercetin may help extend the lifespan of animals in animal studies.[12]

Zinc

Zinc is a powerful mineral that’s necessary to life. So necessary in fact, that it is required for at least 100 different metabolic pathways in the body — including those related to healing, immunity, and growth of new cells.[13]

You may already be familiar with how it helps bolster immune health. Many people take zinc lozenges at the first sign of a cold, and for good reason: they may help to reduce the length of a cold by nearly three days.[14]

And because of its necessity in so many different biological functions, maintaining an adequate supply of zinc helps ensure that your health is optimized. 

Zinc also possesses some anti-aging properties, especially when applied topically as a skin protectant (zinc oxide, a key ingredient in many sunscreens).[15]

Vitamin C

Vitamin C is probably most well known for its immune-boosting benefits. However, this essential water-soluble vitamin also plays a number of other roles. For instance, it’s a powerful antioxidant and it’s necessary for proper skin functioning and health. 

In regards to immune health, it’s role in the skin is actually quite important. The skin is the body’s largest immune organ, serving as a physical barrier that helps protect the more delicate tissues in your body from pathogens. Vitamin C is also needed for your body to synthesize collagen, which is key for healing and tissue repair. 

Additionally, vitamin C helps immune cells differentiate and multiply in response to a need.[16]

As an antioxidant, vitamin C can help regulate immune function so that the body is able to function more optimally in other processes.

Vitamin D

The final key ingredient in Immune Wellness is vitamin D, an essential fat-soluble vitamin. This vitamin is underrated, but so important for immune health and a number of other body processes.

Unfortunately, most people are deficient in vitamin D. There’s some speculation that we need more vitamin D than previously thought because it is so important.

It helps to keep your bones strong by promoting calcium absorption from the foods you eat. Without vitamin D, your body has more trouble getting calcium from food, so it goes to the next best source: your bones. While this keeps your blood calcium levels normal, your bones slowly become weaker and less dense over the years.[17]

Researchers have also found that being deficient in vitamin D may make you more susceptible to falling ill when you’re exposed to viruses or other potentially harmful organisms.[18]

Summary

Aging of the immune system is an unavoidable part of aging, but can be mitigated by healthy lifestyle practices. The same lifestyle choices that may boost your immune system also provide anti-aging effects and promote optimal health and wellness.

These strategies include:

  • Eating a healthy and balanced diet that’s rich in polyphenols and low in sugar and processed foods
  • Exercising for, ideally, 150-300 minutes per week along with 2 weekly resistance training sessions
  • Getting at least 7-9 hours of good sleep per night consistently
  • Minimizing stress as much as possible

In addition, you should consider taking targeted supplements. Regardless of your lifestyle, supplements can help fill gaps and introduce powerful compounds you may not regularly consume as part of your diet.

One great example is Juvenon’s Immune Wellness, which focuses on both immune support and wellness. It contains a unique blend of the powerful antioxidant polyphenols quercetin and beta-glucan, along with the essential nutrients zinc, vitamin C, and vitamin D that are well known to help modulate the immune system and promote overall wellness.

With just one pill per day, Immune Wellness may help give your immune system the boost it needs to stay strong and vibrant through the winter months, while also helping to optimize your overall health and wellness.

References:

  1. Sadighi Akha AA. Aging and the immune system: An overview. J Immunol Methods. 2018;463:21-26. doi:10.1016/j.jim.2018.08.005
  2. Meccariello R, D’Angelo S. Impact of Polyphenolic-Food on Longevity: An Elixir of Life. An Overview. Antioxidants (Basel). 2021;10(4):507. Published 2021 Mar 24. doi:10.3390/antiox10040507
  3. Shomali N, Mahmoudi J, Mahmoodpoor A, et al. Harmful effects of high amounts of glucose on the immune system: An updated review. Biotechnol Appl Biochem. 2021;68(2):404-410. doi:10.1002/bab.1938
  4. Campbell JP, Turner JE. Debunking the Myth of Exercise-Induced Immune Suppression: Redefining the Impact of Exercise on Immunological Health Across the Lifespan. Front Immunol. 2018;9:648. Published 2018 Apr 16. doi:10.3389/fimmu.2018.00648
  5. Besedovsky L, Lange T, Haack M. The Sleep-Immune Crosstalk in Health and Disease. Physiol Rev. 2019;99(3):1325-1380. doi:10.1152/physrev.00010.2018
  6. Dragoş D, Tănăsescu MD. The effect of stress on the defense systems. J Med Life. 2010;3(1):10-18.
  7. Sheng K, Wang C, Chen B, et al. Recent advances in polysaccharides from Lentinus edodes (Berk.): Isolation, structures and bioactivities. Food Chem. 2021;358:129883. doi:10.1016/j.foodchem.2021.129883
  8. Moerings BGJ, de Graaff P, Furber M, et al. Continuous Exposure to Non-Soluble β-Glucans Induces Trained Immunity in M-CSF-Differentiated Macrophages. Front Immunol. 2021;12:672796. Published 2021 Jun 2. doi:10.3389/fimmu.2021.672796
  9. Song L, Zhou Y, Ni S, et al. Dietary Intake of β-Glucans Can Prolong Lifespan and Exert an Antioxidant Action on Aged Fish Nothobranchius guentheri. Rejuvenation Res. 2020;23(4):293-301. doi:10.1089/rej.2019.2223
  10. Song L, Yuan J, Ni S, et al. Enhancement of adaptive immune responses of aged mice by dietary intake of β-glucans, with special emphasis on anti-aging activity. Mol Immunol. 2020;117:160-167. doi:10.1016/j.molimm.2019.10.019
  11. Chen X, Liang D, Huang Z, Jia G, Zhao H, Liu G. Anti-fatigue effect of quercetin on enhancing muscle function and antioxidant capacity [published online ahead of print, 2021 Oct 14]. J Food Biochem. 2021;e13968. doi:10.1111/jfbc.13968
  12. Blagosklonny MV. Anti-aging: senolytics or gerostatics (unconventional view). Oncotarget. 2021;12(18):1821-1835. Published 2021 Aug 31. doi:10.18632/oncotarget.28049
  13. National Institutes of Health. Zinc fact sheet for health professionals. Updated March 26, 2021. Retrieved from https://ods.od.nih.gov/factsheets/Zinc-HealthProfessional/
  14. Hemilä H, Petrus EJ, Fitzgerald JT, Prasad A. Zinc acetate lozenges for treating the common cold: an individual patient data meta-analysis. Br J Clin Pharmacol. 2016;82(5):1393-1398. doi:10.1111/bcp.13057
  15. Cabot C, Sibole JV, Barceló J, Poschenrieder C. Luxury zinc supply acts as antiaging agent and enhances reproductive fitness in Arabidopsis thaliana. Plant Sci. 2021;304:110805. doi:10.1016/j.plantsci.2020.110805
  16. Carr AC, Maggini S. Vitamin C and Immune Function. Nutrients. 2017;9(11):1211. Published 2017 Nov 3. doi:10.3390/nu9111211
  17. National Institutes of Health. Vitamin D fact sheet for health professionals. Updated August 17, 2021. https://ods.od.nih.gov/factsheets/VitaminD-HealthProfessional/
  18. Despland C, Gilliand M, Schaub C. Carence en vitamine D et immunité sous-optimale : un défi en période de Covid [Vitamin D deficiency and suboptimal immunity : A challenge during Covid pandemia]. Rev Med Suisse. 2021;17(753):1711-1716.